Filaggrin gene defects and the risk of developing allergic disorders

Skin barrier defects caused by filaggrin gene mutations allow allergens to penetrate the epidermis and interact with antigen-presenting cells, leading to the development of atopic disorders, including asthma. Studies have shown that between 25-50% of patients with atopic dermatitis have filaggrin mutations. These mutations are also linked to atopic dermatitis-associated asthma and allergic rhinitis. In the case of atopic dermatitis, restoration of the skin barrier function seems to be a good prophylactic strategy.  

Source: Allergology International

January 2011

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